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Phenotypes Associated with This Genotype
Genotype
MGI:6119492
Allelic
Composition		 Tagln2tm1Cdj/Tagln2tm1Cdj
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tagln2tm1Cdj mutation (0 available); any Tagln2 mutation (21 available)
Tg(TcraTcrb)425Cbn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:256656 )
• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation

hematopoietic system
abnormal T cell activation ( J:256656 )
• purified CD4+ and CD8+ T cells respectively, showed a significant reduction in IFNG and IL-2 protein levels and decreased proliferation in response to stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory