Phenotypes Associated with This Genotype

Genotype
MGI:6119491

• Allelic Composition: Tagln2^tm1Cdj/Tagln2^tm1Cdj
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:256656 )

N • no abnormalities in secondary lymphoid organ weight or size, T cell development, or B cell development are detected

N • B-cell and dendritic cell response to lipopolysaccharide is similar to controls

abnormal T cell physiology ( J:256656 )

• CD3+ T cells show impaired cell spreading and F-actin ring formation following stimulation on anti-CD3/28-coated coverslips

• CD3+ T cells show reduced conjugate formation with SEE-loaded CD19+ B cells from wild-type mice and impaired ability to adhere to ICAM-1

abnormal cytotoxic T cell physiology ( J:256656 )

• CD8+ T cells appear to have reduced cytotoxicity

hematopoietic system

abnormal T cell physiology ( J:256656 )

• CD3+ T cells show impaired cell spreading and F-actin ring formation following stimulation on anti-CD3/28-coated coverslips

• CD3+ T cells show reduced conjugate formation with SEE-loaded CD19+ B cells from wild-type mice and impaired ability to adhere to ICAM-1

abnormal cytotoxic T cell physiology ( J:256656 )

• CD8+ T cells appear to have reduced cytotoxicity