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Phenotypes Associated with This Genotype
Genotype
MGI:6118910
Allelic
Composition
H2-K1d-em4Dvs/H2-K1d-em4Dvs
Genetic
Background
NOD/ShiLtDvs-H2-K1d-em4Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-K1d-em4Dvs mutation (1 available); any H2-K1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• insulitis is decreased at 10-15 weeks of age and diabetes onset is delayed and less severe, but not ablated, relative to wild-type
• fewer CD8+ T cells and more CD4+ T cells in the islets than in NOD controls and these CD8+ cells have a higher percentage of CD62L negative/CD44+ effector cells than in NOD controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory