Phenotypes Associated with This Genotype

Genotype
MGI:6117712

• Allelic Composition: Tg(Smoc2-EGFP)HY194Gsat/0
• Genetic Background: involves: FVB/NTac * IcrTac:ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney interstitium morphology ( J:244221 )

• myofibroblast accumulation in mice subjected to unilateral ureteral obstruction or treated with FA

renal fibrosis ( J:244221 )

• kidney fibrosis and tubulointerstitial fibrosis in mice subjected to unilateral ureteral obstruction or treated with FA

homeostasis/metabolism

increased susceptibility to injury ( J:244221 )

• mice subjected to unilateral ureteral obstruction or treated with FA exhibit increased kidney fibrosis with increased interstitial myofibroblast accumulation compared with wild-type mice