Phenotypes Associated with This Genotype

Genotype
MGI:6117394

• Allelic Composition: Spata2^{tm1(KOMP)Vlcg}/Spata2^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6-Spata2^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell death ( J:244164 )

• MEFs and BMDMs resistant to necroptosis induced by a combination of Tnf and IDN-6556 and MEFs to necroptosis induced by a combination of Tnf and zVAD.fmk

• MEFs partially resistant to necroptosis induced by a combination of Tnf and cycloheximide

• MEFs partially resistant to necroptosis induced by a combination of Tnf and (5Z)-7-oxozeaenol

• MEFs resistant to necroptosis induced by a combination of Tnf and TPCA-1

• MEFs sensitive to necroptosis induced by a combination of Tnf and SM-164

immune system

increased inflammatory response ( J:244164 )

• challenge with a sub-lethal (for wild-type) dose of Tnf, to mimic systemic inflammatory response syndrome (SIRS), is fatal

• increased levels of Il6 and Il10 cytokines and increased Mapk8 activation after Tnf challenge

• increased sensitivity to challenge with high dose of lipopolysaccharide: earlier drop in body temperature, higher serum levels of Tnf and Il6, and death 14-18 hours post-injection

growth/size/body

growth/size/body region phenotype ( J:244164 )

N • no obvious phenotype

reproductive system

reproductive system phenotype ( J:244164 )

N • fertile