Analysis Tools
immune system
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• 7 week old females immunized with MOG35-55 peptide and injected with AP20187 10 days later develop milder experimental autoimmune encephalomyelitis (EAE) symptoms at the peak of disease compared to controls, with no mutants developing hind-limb paralysis and reduced myelin damage and axon loss and degeneration in lumbar spinal cord
• mice undergoing EAE and treated with AP20187 exhibit reduced number of apoptotic oligodendrocytes and Pdgfar+ OPCs in the lumbar spinal cord
• however, AP20187 treatment does not alter the degree of the inflammatory response in the CNS of mutant mice undergoing EAE compared to controls
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nervous system
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• mice injected intraperitoneally with AP20187 at 6 weeks of age daily for 4 weeks are indistinguishable from controls, with normal numbers of CC1+ oligodendrocytes, normal myelin and normal numbers of Pdgfar+ oligodendrocyte progenitor cells
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