Analysis Tools
behavior/neurological
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• although no ataxia is apparent at P45, heterozygotes show a 55% reduction in their ability to remain on an accelerating rotarod relative to wild-type controls, indicating a motor deficit
• however, no Purkinje cell loss or abnormal cerebellum morphology are observed
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homeostasis/metabolism
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• in the neonatal cerebellum, phosphatase activity toward soluble phosphoinositol substrates is reduced to an intermediate level relative to homozygotes
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