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Phenotypes Associated with This Genotype
Genotype
MGI:6115340
Allelic
Composition		 Tnni3ktm1Tfo/Tnni3ktm1Tfo
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Tnni3ktm1Tfo mutation (0 available); any Tnni3k mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased myocardial fiber number ( J:249318 )
• 2.5 fold increase in mononuclear cardiomyocyte frequency
• 3 fold increase in mononuclear diploid cardiomyocytes (MNDCMs)

muscle
increased myocardial fiber number ( J:249318 )
• 2.5 fold increase in mononuclear cardiomyocyte frequency
• 3 fold increase in mononuclear diploid cardiomyocytes (MNDCMs)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory