Phenotypes Associated with This Genotype

Genotype
MGI:6115339

• Allelic Composition: Tnni3k^tm1.1Tfo/Tnni3k^tm1.1Tfo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber number ( J:249318 )

• 2.5 fold increase in mononuclear cardiomyocyte frequency

• 3 fold increase in mononuclear diploid cardiomyocytes (MNDCMs)

abnormal myocardial fiber physiology ( J:249318 )

• following coronary ligation, a 3 fold increase in proliferating (EdU-labelled) cardiomyocytes is observed at the injury border zone as compared to controls

• this cardiomyocyte population exhibits an increase in tetraploid nuclei

• 58.4% of EdU-labelled cardiomyocytes complete cytokinesis as compared to 14.8% in controls

cellular

abnormal cell proliferation ( J:249318 )

• following coronary ligation, a 3 fold increase in proliferating (EdU-labelled) cardiomyocytes is observed at the injury border zone as compared to controls

muscle

muscle phenotype ( J:249318 )

N • following coronary ligation, heart function, scar area, and cardiomyocyte size are similar to controls

increased myocardial fiber number ( J:249318 )

• 2.5 fold increase in mononuclear cardiomyocyte frequency

• 3 fold increase in mononuclear diploid cardiomyocytes (MNDCMs)

abnormal myocardial fiber physiology ( J:249318 )

• following coronary ligation, a 3 fold increase in proliferating (EdU-labelled) cardiomyocytes is observed at the injury border zone as compared to controls

• this cardiomyocyte population exhibits an increase in tetraploid nuclei

• 58.4% of EdU-labelled cardiomyocytes complete cytokinesis as compared to 14.8% in controls