Phenotypes Associated with This Genotype

Genotype
MGI:6115217

• Allelic Composition: Svep1^{tm1b(EUCOMM)Hmgu}/Svep1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: B6N(Cg)-Svep1^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0747_6_B06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:255307 )

• no homozygotes are identified at weaning

homeostasis/metabolism

edema ( J:255307 )

• E18.5 homozygotes exhibit edema

integument

acanthosis ( J:255307 )

• E18.5 homozygotes exhibit significant acanthosis relative to heterozygous controls

thick epidermis ( J:255307 )

• E18.5 homozygotes exhibit a significantly thicker epidermal layer relative to heterozygous controls

abnormal skin coloration ( J:255307 )

• E18.5 homozygotes exhibit abnormal skin coloration

limbs/digits/tail

abnormal limb morphology ( J:255307 )

• at E18.5

abnormal tail morphology ( J:255307 )

• at E18.5