Phenotypes Associated with This Genotype

Genotype
MGI:6115035

• Allelic Composition: Pi16^tm1.2Engl/Pi16^tm1.2Engl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:244259 )

N • heart weight to body weight ratio (no hypertrophy) and extent of extracellular matrix (no fibrosis) at 8 months old

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:244259 )

N • basal blood parameters recorded 1, 3, 5 and 8 months postnatal: WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, MPV

abnormal homeostasis ( J:244259 )

• fails to inhibit proteolytic activation of chemokine pro-chemerin (Rarres2)

immune system

abnormal immune system physiology ( J:244259 )

• fails to inhibit proteolytic activation of chemokine pro-chemerin (Rarres2)

reproductive system

reproductive system phenotype ( J:244259 )

N • litter size and sex balance