Phenotypes Associated with This Genotype

Genotype
MGI:6113543

• Allelic Composition: Rrn3^tm1.1Igt/Rrn3^tm1.1Igt; Tg(Slc6a3-icre)9190Gsc/0
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:168232 )

• mice exhibit abnormal behavior at 4 weeks of age, starting with slowness of movements

impaired coordination ( J:168232 )

• mice show an approximate 55% reduction in motor performance on the accelerating rotarod at 4 weeks of age, reaching a 76% decline at 8 weeks of age

jerky movement ( J:168232 )

• mice eventually develop twitching similar to Parkinsons disease tremor

abnormal posture ( J:168232 )

• mice exhibit posture disturbances at 4 weeks of age

abnormal gait ( J:168232 )

• mice exhibit abnormal gait at 4 weeks of age

cellular

abnormal nucleolus morphology ( J:168232 )

• nucleolar disruption in dopaminergic neurons is seen at E18.5

growth/size/body

slow postnatal weight gain ( J:168232 )

• mice show a progressive reduction in weight gain after P15

• mice with severe phenotype treated with the dopamine precursor L-DOPA survive and grain weight

homeostasis/metabolism

decreased dopamine level ( J:168232 )

• 95% reduction of dopamine levels at 5 weeks of age

nervous system

loss of dopaminergic neurons ( J:168232 )

• decrease in the number of dopaminergic neurons, with neurons in the substantia nigra more rapidly and severely affected than those in the ventral tegmental area

• TH immunoreactivity in dopaminergic neuron terminals in the striatum is decreased already at P0, before the loss of neurons

neurodegeneration ( J:168232 )

• of dopaminergic neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:168232