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Phenotypes Associated with This Genotype
Genotype
MGI:6113359
Allelic
Composition		 Rab20tm1a(EUCOMM)Hmgu/Rab20tm1a(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab20tm1a(EUCOMM)Hmgu mutation (1 available); any Rab20 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage physiology ( J:243883 )
• M. tuberculosis-infected bone-marrow-derived macrophages exposed to IFN-gamma fail to exhibit an enlargement of M. tuberculosis-containing phagosomes unlike in wild-type cells and fail to maintain spacious proteolytic phagolysosomes

immune system
abnormal macrophage physiology ( J:243883 )
• M. tuberculosis-infected bone-marrow-derived macrophages exposed to IFN-gamma fail to exhibit an enlargement of M. tuberculosis-containing phagosomes unlike in wild-type cells and fail to maintain spacious proteolytic phagolysosomes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory