Phenotypes Associated with This Genotype

Genotype
MGI:6112616

• Allelic Composition: Gt(ROSA)26Sor^{tm3(Irf4)Evdr}/Gt(ROSA)26Sor⁺; Tg(Ucp1-cre)1Evdr/0
• Genetic Background: involves: 129 * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal adipose tissue development ( J:214637 )

• reduced lipogenesis in brown adipocytes

decreased body fat mass ( J:214637 )

• on standard chow and a high-fat diet

abnormal white fat cell size ( J:214637 )

• less hypertrophy when fed a high-fat diet than in control mice

decreased epididymal fat pad weight ( J:214637 )

• on a high-fat diet

decreased inguinal fat pad weight ( J:214637 )

• on a high-fat diet

browned white adipose tissue morphology ( J:214637 )

homeostasis/metabolism

increased energy expenditure ( J:214637 )

• on a high-fat diet

increased carbon dioxide production ( J:214637 )

• on a high-fat diet

increased oxygen consumption ( J:214637 )

• on a high-fat diet

improved glucose tolerance ( J:214637 )

• on a high-fat diet

increased insulin sensitivity ( J:214637 )

• on a high-fat diet

growth/size/body

decreased body fat mass ( J:214637 )

• on standard chow and a high-fat diet

decreased body weight ( J:214637 )

• on standard chow and a high-fat diet

behavior/neurological

behavior/neurological phenotype ( J:214637 )

N • mice exhibit normal food intake and physical activity when fed standard chow or a high-fat diet

cellular

abnormal cellular respiration ( J:214637 )

• increased uncoupled respiration in brown adipose tissue mitochondria