Phenotypes Associated with This Genotype

Genotype
MGI:6112018

• Allelic Composition: Med28^tm1.2Vra/Med28^tm1.2Vra
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:243694 )

• peri-implantation lethality, with embryos failing to survive shortly after implantation

embryo

absent inner cell mass proliferation ( J:243694 )

• E3.5 cultured blastocysts do not show well-developed inner cell mass outgrowths as seen in controls

absent embryonic epiblast ( J:243694 )

• embryos lack an epiblast

absent egg cylinders ( J:243694 )

• embryos show no egg cylinder structure

abnormal blastocyst morphology ( J:243694 )

• maker analysis of intact E3.5 and cultured blastocysts indicates that they lack pluripotency

disorganized extraembryonic tissue ( J:243694 )

cellular

absent inner cell mass proliferation ( J:243694 )

• E3.5 cultured blastocysts do not show well-developed inner cell mass outgrowths as seen in controls