Phenotypes Associated with This Genotype

Genotype
MGI:6111184

• Allelic Composition: Hnmt^{tm1a(KOMP)Wtsi}/Hnmt^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0109_4_D09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:253575 )

N • mice do not exhibit anxiety-like behaviors in an elevated plus-maze, zero-maze or light/dark box test or depressive-like behavior in a forced swim test

N • mice exhibit normal food intake, working memory in a Y-maze, learning/memory in a passive avoidance test, motor control, motor activity, pain sensitivity and social interaction

increased aggression towards mice ( J:253575 )

• in the resident-intruder test

increased aggression towards male mice ( J:253575 )

• treatment with an H1R antagonist has no effect

• increased male on male aggression without an increase in testosterone

• however, treatment with an H2R antagonist decreased number of attacks

decreased locomotor activity ( J:253575 )

• in an open field and home cage

• prolonged immobile time during the dark period

• however, time spent in the center is normal

abnormal sleep pattern ( J:253575 )

• increased wakefulness during ZT0-6 (inactive period) with increased average wake bout duration and decreased wakefulness during ZT12-18 (active period)

• increased EEG activity in the 3.0-5.5 Hz range during wakefulness

• however, the number of wake and sleep bouts and EEG activities during REM sleep are normal

abnormal non-rapid eye movement sleep pattern ( J:253575 )

• lower EEG theta activity during both the light and dark phase

homeostasis/metabolism

increased histamine level ( J:253575 )

• 5-fold higher histamine levels in the cortex, diencephalon, brainstem and cerebellum compared with wild-type mice

• higher extracellular histamine levels in the hypothalamus, irrespective of light/dark cycles

• elevated histamine levels in the liver and kidney

• however, mice exhibit normal brain levels of dopamine, norepinephrine, serotonin or related metabolites