Phenotypes for Myh10 MGI:6110154 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Myh10^ehc/Myh10^tm2Rsad
Genetic Background	involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^ehc mutation (0 available); any Myh10 mutation (95 available)
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:248868 )

• in late gestation

cardiovascular system

abnormal heart morphology ( J:248868 )

• authors state that mice exhibit similar heart defects as observed in Myh10^ehc homozygotes

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

absent coronary vessels ( J:248868 )

muscle

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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