Phenotypes Associated with This Genotype

Genotype
MGI:6108115

• Allelic Composition: Hcfc2^fkls/Hcfc2^fkls
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:251008 )

• all HSV1-infected mice die unlike wild-type mice

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:251008 )

• all influenza A--infected mice die unlike wild-type mice

immune system

decreased circulating interferon-alpha level ( J:251008 )

• in HSV1-infected mice

decreased circulating interferon-beta level ( J:251008 )

• in HSV1-infected mice

decreased interferon-beta secretion ( J:251008 )

• in peritoneal macrophages stimulated with poly(I:C)

decreased tumor necrosis factor secretion ( J:251008 )

• from macrophages of mice stimulated with poly(I:C)

• however, TNF production in response to Pam3CSK4, MALP-1, LPS, flagellin, R848 and CpG-ODN 1668 is normal

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:251008 )

• all influenza A--infected mice die unlike wild-type mice

increased susceptibility to Herpesvirales infection ( J:251008 )

• HSV1-infected mice exhibit reduced circulating IFNa and b and die unlike wild-type mice

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:251008 )

• all HSV1-infected mice die unlike wild-type mice

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:251008 )

• in HSV1-infected mice

decreased circulating interferon-beta level ( J:251008 )

• in HSV1-infected mice