Phenotypes Associated with This Genotype

Genotype
MGI:6107945

• Allelic Composition: Arl8b^tm1Kkon/Arl8b^tm1Kkon; Tg(Ttr-cre)1Hadj/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased embryo size ( J:245627 )

• at E8.5

abnormal embryonic tissue physiology ( J:245627 )

• decreased amino acid levels in the embryo

abnormal visceral yolk sac morphology ( J:245627 )

• the visceral yolk sac is relatively opaque at E8.5

abnormal visceral yolk sac endoderm morphology ( J:245627 )

• hypertrophic visceral yolk sac endoderm with accumulation of vesicles at E8.5

abnormal extraembryonic tissue physiology ( J:245627 )

• accumulation of maternal albumin and IgG and impaired maturation of cathepsin L in the visceral yolk sac

• reduced levels of almost all amino acids and metabolites produced by the central metabolic pathways in the visceral yolk sac

homeostasis/metabolism

abnormal amino acid level ( J:245627 )

• decreased amino acid levels in the embryo

growth/size/body

decreased embryo size ( J:245627 )

• at E8.5