Phenotypes Associated with This Genotype

Genotype
MGI:6107697

• Allelic Composition: Thap1^tm1.2Meeh/Thap1^tm1.2Meeh
• Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal axon extension ( J:226849 )

• few Tuj1-immunopositive neurons

• no obvious processes on Tuj1-immunopositive neurons

liver/biliary system

absent liver ( J:226849 )

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:226849 )

• most embryos died by E10, but rare survivors up to E14

nervous system

abnormal axon extension ( J:226849 )

• few Tuj1-immunopositive neurons

• no obvious processes on Tuj1-immunopositive neurons

decreased brain size ( J:226849 )

enlarged brain ventricles ( J:226849 )

vision/eye

anophthalmia ( J:226849 )