Phenotypes Associated with This Genotype

Genotype
MGI:6107174

• Allelic Composition: Grb10^tm1.1Fliu/Grb10^tm1.1Fliu; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased body fat mass ( J:213603 )

• when standard chow despite lean mass

• when fed a high-fat diet despite no increase in food intake

increased brown fat cell size ( J:213603 )

• when fed standard chow or a high-fat diet

whitened brown adipose tissue morphology ( J:213603 )

• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice

increased white fat cell size ( J:213603 )

• in epididymal and inguinal white adipose tissues when fed standard chow or a high-fat diet

• however, cell number is normal

abnormal epididymal fat pad morphology ( J:213603 )

• enlarged

growth/size/body

increased body fat mass ( J:213603 )

• when standard chow despite lean mass

• when fed a high-fat diet despite no increase in food intake

increased body weight ( J:213603 )

• at 3 and 6 months

increased susceptibility to age related obesity ( J:213603 )

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

increased circulating insulin level ( J:213603 )

• when fed a high-fat diet

impaired glucose tolerance ( J:213603 )

• when fed a high-fat diet

insulin resistance ( J:213603 )

• when fed a high-fat diet

liver/biliary system

hepatic steatosis ( J:213603 )

• when fed a high-fat diet