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Phenotypes Associated with This Genotype
Genotype
MGI:6107172
Allelic
Composition
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (18 available)
Prdm16tm1.1Brsp mutation (1 available); any Prdm16 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• pale axillary and cervical brown adipose tissue depots
• however, tissue mass is not altered
• in the interscapular brown adipose tissue of mice older than 6 months
• in the interscapular brown adipose tissue of mice older than 6 months
• whitening in mice older than 6 months with increased size of the tissue, a switch from multilocular to unilocular morphology, and increased lipid content
• in unstimulated interscapular brown adipose tissue
• whitening in mice older than 6 months with increased size of the tissue, a switch from multilocular to unilocular morphology, and increased lipid content
• 3 week old mice fed a high-fat diet exhibit loss of normal brown adipocyte morphology unlike wild-type mice
• in mice older than 6 months
• however, juvenile mice exhibit normal sized brown adipose tissue depots
• precipitous drop in body temperature following exposure to cold
• however, diet-induced thermogenesis is normal
• reduced basal in interscapular brown adipose tissue

homeostasis/metabolism
• precipitous drop in body temperature following exposure to cold

growth/size/body
• at all ages

cellular
• in unstimulated interscapular brown adipose tissue
• reduced basal in interscapular brown adipose tissue
• with poorly organized cristae in unstimulated interscapular brown adipose tissue


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/31/2026
MGI 6.24
The Jackson Laboratory