Phenotypes Associated with This Genotype

Genotype
MGI:6105954

• Allelic Composition: Stard7^{tm1a(EUCOMM)Wtsi}/Stard7⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0176_3_A10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

respiratory system phenotype ( J:242746 )

N • after sensitization by i.p. injection of OVA on days 0 and 7, followed by intratracheal challenge with OVA on days 18-21

lung inflammation ( J:242746 )

increased airway responsiveness ( J:242746 )

abnormal respiratory epithelial transmembrane transport ( J:242746 )

• increased epithelial barrier permeability

immune system

immune system phenotype ( J:242746 )

N • after sensitization and challenge with OVA

increased CD11b-high dendritic cell number ( J:242746 )

• in lung and lung-draining lymph nodes

increased susceptibility to type I hypersensitivity reaction ( J:242746 )

lung inflammation ( J:242746 )

dermatitis ( J:242746 )

• skin lesions, mainly on ears and back

• vigorous scratching

integument

integument phenotype ( J:242746 )

N • from 6-7 months after sensitization and challenge with OVA

dermatitis ( J:242746 )

• skin lesions, mainly on ears and back

• vigorous scratching

thick epidermis ( J:242746 )

• in skin lesions

hematopoietic system

hematopoietic system phenotype ( J:242746 )

N • after sensitization and challenge with OVA

increased CD11b-high dendritic cell number ( J:242746 )

• in lung and lung-draining lymph nodes

endocrine/exocrine glands

abnormal mucous gland morphology ( J:242746 )

• pulmonary mucous cell metaplasia after sensitization and challenge with OVA