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Phenotypes Associated with This Genotype
Genotype
MGI:6105949
Allelic
Composition
Gnstm1e(EUCOMM)Hmgu/Gnstm1e(EUCOMM)Hmgu
Genetic
Background
C57BL/6N-Atm1Brd Gnstm1e(EUCOMM)Hmgu
Cell Lines HEPD0697_8_B06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnstm1e(EUCOMM)Hmgu mutation (0 available); any Gns mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in open field test
• less distance travelled
• more resting time
• less rearing on hindlimbs

cellular
• lysosomal distension in liver, heart, lung, kidney and urinary bladder
• several-fold increase in GAG (glycosaminoglycan) content in liver, kidney and spleen

hematopoietic system
• in the frontal, parietal and occipital cortices of the encephalon, and the superior colliculus and thalamus at 2 months

immune system
• in the frontal, parietal and occipital cortices of the encephalon, and the superior colliculus and thalamus at 2 months

mortality/aging
• median survival of 16.3 months

nervous system
• in the frontal, parietal and occipital cortices of the encephalon, and the superior colliculus and thalamus at 2 months
• in the frontal, parietal and occipital cortices of the encephalon, and the superior colliculus and thalamus at 2 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
mucopolysaccharidosis III DOID:12801 OMIM:252940
J:242250


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory