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Phenotypes Associated with This Genotype
Genotype
MGI:6105930
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
X/Yaa
Genetic
Background		 BXSB.B6-Il15tm1Imx/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (23 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to systemic lupus erythematosus ( J:179430 )
• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males also homozygous for this null allele of beta-2 microglobulin die much earlier, with a mean survival of only approximately 20 weeks

mortality/aging

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory