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Phenotypes Associated with This Genotype
Genotype
MGI:6099058
Allelic
Composition
Tg(Th-SNCA*A30P*A53T)39Eric/0
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-SNCA*A30P*A53T)39Eric mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• locomotor activity is only 60% of littermate controls by 21-23 months of age
• treatment with a high dose of apomorphine increases locomotor activity to 171% of their habituation control levels
• mice exposed to progressive treatments of combined pesticides show a persistent reduction of about 70% in locomotor activity

homeostasis/metabolism
• mice exposed to combined pesticides exhibit a 56% decrease in the level of dopamine and decreased trends for its metabolites
• dopamine turnover is elevated by 50% in mice exposed to combined pesticides
• mice exposed to progressive treatments of combined pesticides show a persistent reduction of about 70% in locomotor activity
• mice treated with combined pesticides show a greater loss of dopaminergic (TH+) neurons than control littermates
• mice exposed to combined pesticides exhibit a 56% decrease in the level of dopamine and decreased trends for its metabolites, a 40% reduction in dihydroxyphenylacetic acid (DOPAC) levels, a 20% non-statistically significant decrease in homovanillic acid, and a 50% elevation in dopamine turnover
• however, no changes in 5HT levels in the striatum are seen in mice exposed to combined pesticides

nervous system
• mice show a significant loss of TH+ neurons across time in the substantia nigra pars compacta, with an approximate 19% loss at 8.5 months and approximate 55% loss at 19 months of age
• however, inclusions are not seen in the substantia nigra pars compacta
• mice treated with combined pesticides show a greater loss of dopaminergic (TH+) neurons than control littermates

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:607688
OMIM:610297
OMIM:613643
OMIM:614251
OMIM:PS168600
J:96494


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory