Phenotypes Associated with This Genotype

Genotype
MGI:6098730

• Allelic Composition: Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi}; Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
• Cell Lines: EPD0105_5_A09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal cochlea morphology ( J:246055 )

• increased actin aggregation in the adherens-junction region and expansion of the apical surface

decreased cochlear hair cell stereocilia number ( J:246055 )

• no distinguishable stereocilia

cochlear hair cell degeneration ( J:246055 )

• reduction in stereocilia diameter and length eventually followed by disappearance

abnormal cuticular plate morphology ( J:246055 )

• ruptures

abnormal vestibular hair cell stereociliary bundle morphology ( J:246055 )

• disrupted hair cell in some bundles

short vestibular hair cell stereocilia ( J:246055 )

• with decreased width

nervous system

decreased cochlear hair cell stereocilia number ( J:246055 )

• no distinguishable stereocilia

cochlear hair cell degeneration ( J:246055 )

• reduction in stereocilia diameter and length eventually followed by disappearance

abnormal vestibular hair cell stereociliary bundle morphology ( J:246055 )

• disrupted hair cell in some bundles

short vestibular hair cell stereocilia ( J:246055 )

• with decreased width