Phenotypes Associated with This Genotype

Genotype
MGI:6098728

• Allelic Composition: Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi}; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: C57BL/6N * CBA * SJL
• Cell Lines: EPD0105_5_A09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:246055 )

absent distortion product otoacoustic emissions ( J:246055 )

abnormal vestibular system physiology ( J:246055 )

• strongly reduced vestibular function

absent linear vestibular evoked potential ( J:246055 )

• undetectable in 4 of 5 mice

behavior/neurological

head shaking ( J:246055 )

• progressively worse after weaning

• however, mice do not exhibit circling