Phenotypes for H2-D1 H2-K1 Yaa MGI:6094247 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe X/Yaa
Genetic Background	BXSB.129P2(B6)-H2-K1^b-tm1Bpe H2-D1^b-tm1Bpe/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1^b-tm1Bpe mutation (9 available); any H2-D1 mutation (45 available)
H2-K1^b-tm1Bpe mutation (9 available); any H2-K1 mutation (59 available)
Yaa mutation (18 available); any Yaa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of MHC class I molecules intensifies the severity to a mean survival of only 25 weeks of age

mortality/aging

premature death ( J:179430 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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