Phenotypes Associated with This Genotype

Genotype
MGI:6094214

• Allelic Composition: Lifr^tm1Imx/Lifr⁺
• Genetic Background: B6;129S7-Lifr^tm1Imx/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

cryptorchism ( J:242320 )

♂ • 42.5% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism

renal/urinary system

abnormal ureter morphology ( J:242320 )

• reduction of the proximal, medial and distal ureteric lumen at E18.5, but to a lesser extent than in homozygotes

hydroureter ( J:242320 )

• 5% of E18.5 fetuses exhibit severe hydroureter

reproductive system

cryptorchism ( J:242320 )

♂ • 42.5% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism