Phenotypes for B2m Yaa MGI:6094201 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	B2m^tm1Unc/B2m^tm1Unc X/Yaa
Genetic Background	BXSB.129P2(B6)-B2m^tm1Unc/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Unc mutation (36 available); any B2m mutation (119 available)
Yaa mutation (23 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males also homozygous for this null allele of beta-2 microglobulin die much earlier, with a mean survival of only 18 weeks

increased anti-nuclear antigen antibody level ( J:179430 )

• despite the inability to generate serum IgG, there is increased anti-nuclear antibodies in the serum at 14 weeks of age, that is higher than that of BXSB/MpJ males with normal B2M expression

mortality/aging

premature death ( J:179430 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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