Phenotypes Associated with This Genotype

Genotype
MGI:5925346

• Allelic Composition: Npc1^m1N/Npc1^tm1.1Apl; Tg(Syn1-cre)671Jxm/0
• Genetic Background: B6J.Cg-Npc1^m1N/Npc1^tm1.1Apl Tg(Syn1-cre)671Jxm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:176888 )

• mice show early death, with an average lifespan of 105 days

nervous system

astrocytosis ( J:176888 )

• mice show activated astrocytes in many brain regions

microgliosis ( J:176888 )

• mice show activated microglia in many brain regions

increased brain cholesterol level ( J:176888 )

abnormal axon morphology ( J:176888 )

• mice show severe axonal pathology

axonal spheroids ( J:176888 )

• mice exhibit frequent axonal spheroids in the brainstem

demyelination ( J:176888 )

• mice show loss of myelinated fibers in the corpus callosum

behavior/neurological

impaired balance ( J:176888 )

• mice develop motor deficits in the balance beam

impaired coordination ( J:176888 )

• mice develop motor deficits in the rotarod

growth/size/body

weight loss ( J:176888 )

• mice exhibit progressive weight loss

hematopoietic system

microgliosis ( J:176888 )

• mice show activated microglia in many brain regions

homeostasis/metabolism

increased brain cholesterol level ( J:176888 )

immune system

microgliosis ( J:176888 )

• mice show activated microglia in many brain regions

cellular

astrocytosis ( J:176888 )

• mice show activated astrocytes in many brain regions

microgliosis ( J:176888 )

• mice show activated microglia in many brain regions