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Phenotypes Associated with This Genotype
Genotype
MGI:5924952
Allelic
Composition
RhoTvrm334/Rho+
Genetic
Background
B6.Cg-RhoTvrm334/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm334 mutation (0 available); any Rho mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the fundus appears grainy, and there is rapid photoreceptor degeneration and thinning of the retinal pigment epithelium, with a slightly thinned outer nuclear layer at 14 days of age and only 3 to 4 rows of photoreceptor nuclei at 21 days of age
• rhodopsin is mislocalized to the soma of photoreceptor cells

nervous system

vision/eye
• the fundus appears grainy, and there is rapid photoreceptor degeneration and thinning of the retinal pigment epithelium, with a slightly thinned outer nuclear layer at 14 days of age and only 3 to 4 rows of photoreceptor nuclei at 21 days of age
• rhodopsin is mislocalized to the soma of photoreceptor cells
• although light adapted (cone) ERG readings are normal at 21 days of age, dark-adapted ERG shows severely diminished rod function

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:243745


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory