Phenotypes Associated with This Genotype

Genotype
MGI:5912396

• Allelic Composition: Nedd9^tm1.1Mcda/Nedd9^tm1.1Mcda
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:229548 )

• slower to learn the location of an escape platform in a Morris water maze in both training and probe trials

nervous system

abnormal hippocampus granule cell morphology ( J:229548 )

• decrease in spine density of hippocampal granule cells of the dentate gyrus and the basal and apical CA1 regions at 6 months of age

• decrease in spine density is relatively uniform across the entire dendritic tree

abnormal dendrite morphology ( J:229548 )

• decrease in total apical but not basal dendritic length in the CA1 region of the hippocampus

decreased dendritic spine density ( J:229548 )

• decrease in spine density of hippocampal granule cells of the dentate gyrus and the basal and apical CA1 regions at 6 months of age

• decrease in spine density is relatively uniform across the entire dendritic tree

abnormal dentate gyrus neuron dendrite morphology ( J:229548 )

• decrease in spine density of hippocampal granule cells of the dentate gyrus and the basal and apical CA1 regions at 6 months of age

• decrease in spine density is relatively uniform across the entire dendritic tree

• decrease in dendritic spine density worsens with age, with spine density reduced by 25%, 53% and 66% at 1.5, 6, and 10 months of age, respectively, compared to controls