Phenotypes Associated with This Genotype

Genotype
MGI:5912229

• Allelic Composition: \Tg(CAG-PPARG*,-tdTomato)#Sig/0; \Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:242422 )

N • food intake

growth/size/body

growth/size/body region phenotype ( J:242422 )

N • body water content

increased body fat mass ( J:242422 , J:242422 )

♀ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

♂ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

decreased lean body mass ( J:242422 , J:242422 )

♀ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

♂ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

decreased body weight ( J:242422 )

♂ • 1 week after 4 days of leptin injections after 25 weeks on 10% fat isocaloric-matched control

increased body weight ( J:242422 , J:242422 )

♀ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

♂ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

adipose tissue

adipose tissue phenotype ( J:242422 )

♂N • gonadal fat pad morphology 1 week after 4 days of leptin injections after 25 weeks on 10% fat isocaloric-matched control diet

increased subcutaneous adipose tissue amount ( J:242422 )

♂ • 1 week after 4 days of leptin injections after 25 weeks on 10% fat isocaloric-matched control diet

increased body fat mass ( J:242422 , J:242422 )

♀ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

♂ • on 10% fat isocaloric-matched control diet or on regular laboratory chow diet containing 18% fat (J:242422)

increased brown adipose tissue mass ( J:242422 )

♂ • 1 week after 4 days of leptin injections after 25 weeks on 10% fat isocaloric-matched control diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:242422 )

N • fasted circulating glucose level

integument

increased subcutaneous adipose tissue amount ( J:242422 )

♂ • 1 week after 4 days of leptin injections after 25 weeks on 10% fat isocaloric-matched control diet