Phenotypes Associated with This Genotype

Genotype
MGI:5912149

• Allelic Composition: Mcur1^{tm1c(KOMP)Wtsi}/Mcur1^{tm1c(KOMP)Wtsi}; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0332_3_A12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:235756 )

• some mice die by 3 weeks of age

• however, some mice are viable

cellular

abnormal mitochondrial physiology ( J:235756 )

• cardiomyocyte mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells

• cardiomyocytes mitochondria exhibit defective inward mitochondrial calcium ion uniporter-dependent inward current compared with control cells

• however, mitochondrial membrane potential is normal

growth/size/body

decreased body size ( J:235756 )