Phenotypes Associated with This Genotype

Genotype
MGI:5912002

• Allelic Composition: Pkn1^tm1Ajmc/Pkn1^tm1Ajmc
• Genetic Background: B6.129P2-Pkn1^tm1Ajmc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system physiology ( J:258572 )

• hearts show a significant decrease in p42/p44-MAPK (ERK1/2) phosphorylation both at baseline and during global ischemia and reperfusion (I/R)

decreased cardiac muscle contractility ( J:258572 )

• the maximal rate of systolic pressure development (dP/dT max) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts

• however, the average dP/dTmax and ejection fraction are relatively normal

decreased cardiac muscle relaxation ( J:258572 )

• the maximal rate of relaxation (dP/dT min) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts

abnormal heart echocardiography feature ( J:258572 )

• Doppler echocardiography revealed that left ventricular (LV) posterior wall thickness at diastole (PWTD) is significantly higher than that in wild-type hearts

decreased left ventricle developed pressure ( J:258572 )

• following I/R, LVDP is significantly lower than that in wild-type hearts (17.7 +/- 3.9% versus 33.6 +/- 6.1%) with no differences in end diastolic pressure (EDP) or coronary flow (CF), indicating increased injury and reduced functional recovery

• however, baseline LVDP, EDP and CF are normal

decreased left ventricle systolic pressure ( J:258572 )

• beat-to-beat systolic pressure (SP) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts

increased myocardial infarct size ( J:258572 )

• following global I/R injury, myocardial infarct size is nearly doubled relative to that in wild-type hearts (45.1 +/- 2.9% versus 25.5 +/- 0.8%)

homeostasis/metabolism

increased myocardial infarct size ( J:258572 )

• following global I/R injury, myocardial infarct size is nearly doubled relative to that in wild-type hearts (45.1 +/- 2.9% versus 25.5 +/- 0.8%)

abnormal calcium ion homeostasis ( J:258572 )

• hearts show a significant increase in basal phospholamban (PLB) Thr¹⁷ phosphorylation, ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca²⁺ transporting 2, aka SERCA2) expression and Jph2 (junctophilin-2) expression, suggesting a compensatory enhancement of sarcoplasmic reticulum Ca²⁺ uptake at baseline

muscle

decreased cardiac muscle contractility ( J:258572 )

• the maximal rate of systolic pressure development (dP/dT max) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts

• however, the average dP/dTmax and ejection fraction are relatively normal

decreased cardiac muscle relaxation ( J:258572 )

• the maximal rate of relaxation (dP/dT min) normalized to the end diastolic pressure (EDP) is significantly lower than that in wild-type hearts

mortality/aging

mortality/aging ( J:229595 )

N • mice are viable and overtly normal

reproductive system

reproductive system phenotype ( J:229595 )

N • mice are fertile