Phenotypes for Tg(Myh6-Camk2d)1Jhb MGI:5912000 MGI Mouse

increased heart left atrium weight ( J:73694 )

• 27% increase I left ventricle to body weight ratio at 12 weeks of age on average

enlarged heart ( J:73694 )

• most mice show enlarged hearts at 3-4 months of age

increased heart weight ( J:73694 )

• a 22% increase in heart weight to body weight ratio on average

cardiac hypertrophy ( J:73694 )

decreased cardiac muscle contractility ( J:73694 )

• decrease in fractional shortening and velocity of circumferential shortening in 3-4 month old mice

• +dP/dt responses to pacing are blunted in hearts

decreased cardiac muscle relaxation ( J:73694 )

• dP/dt responses to pacing are blunted in hearts

abnormal heart echocardiography feature ( J:73694 )

• echocardiography of 3-4 month old mice shows a 14% increase in left ventricular end diastolic diameter and 31% increase in left ventricular end systolic diameter in 3-4 month old mice, a 20% increase in left ventricular mass, and decreased fractional shortening and velocity of circumferential shortening

decreased calcium uptake by cardiac muscle ( J:73694 )

• sarcoplasmic reticulum calcium uptake is decreased in ventricles from 3-4 month old mice