Phenotypes Associated with This Genotype

Genotype
MGI:5911922

• Allelic Composition: Trim38^{tm1(KOMP)Vlcg}/Trim38^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to infection induced morbidity/mortality ( J:239773 )

• poly(I:C) or LPS-induced

increased susceptibility to bacterial infection induced morbidity/mortality ( J:239773 )

• in S. typhimurium-infected mice

immune system

increased circulating interferon-alpha level ( J:239773 )

• poly(I:C) or LPS-induced

increased circulating interferon-beta level ( J:239773 )

• poly(I:C) or LPS-induced

increased circulating interleukin-6 level ( J:239773 )

• poly(I:C) or LPS-induced

increased circulating tumor necrosis factor level ( J:239773 )

• poly(I:C) or LPS-induced

increased susceptibility to bacterial infection ( J:239773 )

• S. typhimurium-infected mice exhibit increased weight gain and lethality with earlier onset of death compared with wild-type mice

increased susceptibility to infection induced morbidity/mortality ( J:239773 )

• poly(I:C) or LPS-induced

increased susceptibility to bacterial infection induced morbidity/mortality ( J:239773 )

• in S. typhimurium-infected mice

homeostasis/metabolism

increased circulating interferon-alpha level ( J:239773 )

• poly(I:C) or LPS-induced

increased circulating interferon-beta level ( J:239773 )

• poly(I:C) or LPS-induced

increased circulating interleukin-6 level ( J:239773 )

• poly(I:C) or LPS-induced

increased circulating tumor necrosis factor level ( J:239773 )

• poly(I:C) or LPS-induced