Phenotypes Associated with This Genotype

Genotype
MGI:5911876

• Allelic Composition: Sgcd^tm1Mcn/Sgcd^tm1Mcn
• Genetic Background: B6.129-Sgcd^tm1Mcn/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cardiac muscle necrosis ( J:234761 )

cardiovascular system

cardiac muscle degeneration ( J:234761 )

• cardiac cell degeneration

cardiac muscle necrosis ( J:234761 )

cardiac fibrosis ( J:234761 )

dilated cardiomyopathy ( J:234761 )

• 14 week old mice develop signs of mild cardiomyopathy with patchy areas of fibrosis and necrosis

decreased cardiac muscle contractility ( J:234761 )

• heart function is reduced with mice showing reduced fractional shortening

muscle

cardiac muscle degeneration ( J:234761 )

• cardiac cell degeneration

cardiac muscle necrosis ( J:234761 )

dilated cardiomyopathy ( J:234761 )

• 14 week old mice develop signs of mild cardiomyopathy with patchy areas of fibrosis and necrosis

decreased cardiac muscle contractility ( J:234761 )

• heart function is reduced with mice showing reduced fractional shortening

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1L		DOID:0110436	OMIM:606685	J:234761