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Phenotypes Associated with This Genotype
Genotype
MGI:5911874
Allelic
Composition
Sgcdtm1Ojml/Sgcd+
Genetic
Background
B6.129-Sgcdtm1Ojml
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgcdtm1Ojml mutation (0 available); any Sgcd mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show increased heart to body weight ratio
• 1 year old mice develop a mild dilated cardiomyopathy phenotype after voluntary wheel running
• however, under baseline conditions, 1 year old hearts do not show histological signs of dilated cardiomyopathy such as cell degeneration, necrosis and fibrosis and echocardiography shows no differences in fractional shortening and preserved left ventricular function

behavior/neurological
• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show reduced cumulative running distance over a period of 4 weeks from the age of 52 weeks

homeostasis/metabolism
• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show reduced cumulative running distance over a period of 4 weeks from the age of 52 weeks
• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show reduced cumulative running distance and increased heart to body weight ratio indicating mild cardiomyopathy

muscle
• 1 year old mice develop a mild dilated cardiomyopathy phenotype after voluntary wheel running
• however, under baseline conditions, 1 year old hearts do not show histological signs of dilated cardiomyopathy such as cell degeneration, necrosis and fibrosis and echocardiography shows no differences in fractional shortening and preserved left ventricular function

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1L DOID:0110436 OMIM:606685
J:234761


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory