Phenotypes Associated with This Genotype

Genotype
MGI:5911578

• Allelic Composition: Col1a1^{tm3(tetO-GFP/RNAi:Stag2)Iaai}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:229031 )

• lineage skewing is seen following prolonged doxycycline exposure (30 days)

decreased B cell number ( J:229031 )

• decrease in the proportion of B cell population (B220+)

increased myeloid cell number ( J:229031 )

• increase in the proportion of myelomonocytic (Cd11b+/Gr1+) and erythroid (CD71+/Ter119+) cells

abnormal hematopoietic stem cell morphology ( J:229031 )

• increase in nuclear size in sorted Lineage-/c-Kit+ progenitor cells not associated with an increase of genomic material or instability

decreased hematopoietic stem cell number ( J:229031 )

• decrease in the number of GFP+ cells in the long-term (CD150+) and short-term (CD150-/CD48-) subsets

immune system

decreased B cell number ( J:229031 )

• decrease in the proportion of B cell population (B220+)