Phenotypes Associated with This Genotype

Genotype
MGI:5910281

• Allelic Composition: Ehmt1^tm1.1Tara/Ehmt1^tm1.1Tara; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased fatty acid oxidation ( J:207678 )

• reduced fatty-acid oxidation capacity in brown adipose tissue

impaired adaptive thermogenesis ( J:207678 )

• temperature drop in cold-exposed mice

increased circulating glucose level ( J:207678 )

increased circulating insulin level ( J:207678 )

• at fasted and glucose-stimulated states

increased circulating free fatty acids level ( J:207678 )

decreased body temperature ( J:207678 )

• temperature drop in cold-exposed mice

abnormal oxygen consumption ( J:207678 )

• loss of induced increase in oxygen consumption after administering CL316,243

impaired glucose tolerance ( J:207678 )

insulin resistance ( J:207678 )

increased liver triglyceride level ( J:207678 )

adipose tissue

increased brown fat cell lipid droplet size ( J:207678 )

increased white fat cell lipid droplet size ( J:207678 )

increased epididymal fat pad weight ( J:207678 )

increased interscapular fat pad weight ( J:207678 )

abnormal brown adipose tissue physiology ( J:207678 )

• reduced fatty-acid oxidation capacity and fatty acid uptake in brown adipose tissue

growth/size/body

increased body weight ( J:207678 )

• without a change in food intake

liver/biliary system

abnormal liver morphology ( J:207678 )

• higher amounts of lipids

increased liver triglyceride level ( J:207678 )

cellular

decreased fatty acid oxidation ( J:207678 )

• reduced fatty-acid oxidation capacity in brown adipose tissue