Phenotypes Associated with This Genotype

Genotype
MGI:5909990

• Allelic Composition: Tmigd3^{Tg(H2-K-CALR*)del52Shmd}/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal megakaryocyte differentiation ( J:241724 )

• more mature

hematopoietic system

increased common myeloid progenitor cell number ( J:241724 )

• in bone marrow

abnormal megakaryocyte morphology ( J:241724 )

• larger diameter

• much higher number of alpha-granules

• increased number of progenitor cells in bone marrow

abnormal megakaryocyte differentiation ( J:241724 )

• more mature

increased megakaryocyte cell number ( J:241724 )

• twofold higher in bone marrow

thrombocytosis ( J:241724 )

• essential thrombocythemia or primary thrombocytosis

• platelet counts as high as 2 10exp12/l

increased megakaryocyte-erythroid progenitor cell number ( J:241724 )

• in bone marrow