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Phenotypes Associated with This Genotype
Genotype
MGI:5908349
Allelic
Composition
Tg(Myh6*)1Lnwd/Tg(Myh6*)1Lnwd
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle

cardiovascular system
• hearts exhibit more severe cellular hypertrophy, myocyte disorganization and small vessel pathology than hemizygous mice
• hearts exhibit small vessel pathology
• mitral valves are thickened with fibrous plaques, and frequent thrombus formation
• mean heart weight-to-tibia length ratio is increased in 10 month old female mice
• systolic anterior wall thickness is greater in 6 month old females
• however, no hypertrophy of the posterior wall in systole or diastole is seen
• echocardiograms of 6 month old females indicated greater anterior wall hypertrophy than in hemizygous mice
• however, systolic function, as assessed by left ventricular shortening fraction, does not differ from wild-type mice

homeostasis/metabolism
• frequent thrombus formation in mitral valves

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 14 DOID:0110320 OMIM:613251
J:55938


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory