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Phenotypes Associated with This Genotype
Genotype
MGI:5908275
Allelic
Composition
Tg(Myh6*)1Lnwd/0
Genetic
Background
involves: C57BL/6 * FVB/N
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phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hearts exhibit cellular hypertrophy, myocyte disorganization and small vessel pathology
• hearts exhibit myocyte disorganization
• heart mass is 40% greater than in wild-type mice at 10 months, but not 2 months of age, indicating development of cardiac hypertrophy
• hypertrophy is restricted to the left ventricle and is not seen in the right ventricle or atria
• hearts exhibit small vessel pathology, with hypertrophied vessels in 10 week old mice
• mitral valves are thickened with fibrous plaques, and frequent thrombus formation
• 1 of 6 mice show tricuspid valve pathology, involving the septal leaflet with a fibrous plaque on the right ventricular septal wall
• systolic anterior wall thickness is greater in 6 month old females
• however, no hypertrophy of the posterior wall in systole or diastole is seen
• ventricular myocytes exhibit reduced rates of relaxation after flash photolysis of diazo 2
• echocardiograms of 6 month old females indicate asymmetric anterior wall hypertrophy
• however, systolic function, as assessed by left ventricular shortening fraction, does not differ from wild-type mice
• ventricular myocytes exhibit decreased calcium sensitivity of tension

homeostasis/metabolism
• frequent thrombus formation in mitral valves

muscle
• hearts exhibit myocyte disorganization
• heart mass is 40% greater than in wild-type mice at 10 months, but not 2 months of age, indicating development of cardiac hypertrophy
• hypertrophy is restricted to the left ventricle and is not seen in the right ventricle or atria
• ventricular myocytes exhibit reduced rates of relaxation after flash photolysis of diazo 2

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 14 DOID:0110320 OMIM:613251
J:55938


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory