Phenotypes Associated with This Genotype

Genotype
MGI:5907351

• Allelic Composition: Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw}; Tg(Myh6-Ppp3ca)37Eno/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:227485 )

• half die by 10 weeks of age and all die by 18 weeks of age

• die earlier than mice carrying Tg(Myh6-Ppp3ca)37Eno alone

• appear to die from heart failure

cardiovascular system

decreased heart left ventricle wall thickness ( J:227485 )

• decrease in left ventricular wall thickness

dilated heart left ventricle ( J:227485 )

• increase in left ventricular dimension and decrease in wall thickness

decreased cardiac muscle contractility ( J:227485 )

• fractional shortening is around 10%

muscle

decreased cardiac muscle contractility ( J:227485 )

• fractional shortening is around 10%