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Phenotypes Associated with This Genotype
Genotype
MGI:5906909
Allelic
Composition		 Stat3tm1Vpo/Stat3+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Vpo mutation (0 available); any Stat3 mutation (72 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
pregnancy-related premature death ( J:141591 )
• postpartum cardiomyopathy-related death is seen after 3-4 deliveries

cardiovascular system
cardiomyopathy ( J:141591 )
• females develop postpartum cardiomyopathy
congestive heart failure ( J:141591 )
• after 4 pregnancies, the majority of females show signs of overt heart failure such as generalized edema and labored breathing

homeostasis/metabolism
generalized edema ( J:141591 )
• females exhibit generalized edema after 4 pregnancies

muscle
cardiomyopathy ( J:141591 )
• females develop postpartum cardiomyopathy

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory