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Phenotypes Associated with This Genotype
Genotype
MGI:5906377
Allelic
Composition
Ptger4tm1.1Matb/Ptger4tm1.1Matb
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger4tm1.1Matb mutation (1 available); any Ptger4 mutation (16 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• length of myocytes from 31-33 week old males is increased, whereas width is normal
• heart weight to body weight ratio is increased in aged males
• males develop eccentric hypertrophy
• dilated left ventricle in males and a slight increase in left ventricular dimension in females
• males show reduced posterior wall thickness at diastole
• 39% increase in interstitial collagen fraction and greater collagen deposition in hearts
• older males show reduced ejection fraction and dilated left ventricle, indicating development of dilated cardiomyopathy
• females develop dilated cardiomyopathy at an older age and to a lesser extent than males
• ejection fraction is lower in 23-33 week old males; two groups are evident, those mice with ejection fraction greater than 70% and those with ejection fraction less than 70%
• 30-32 week old females show a modest, but significant, decline in ejection fraction
• a decline in ejection fraction begins around 16 weeks of age in males and after 24-28 weeks of age in females
• however, systolic blood pressure is normal in males and females at 28 weeks of age
• 28 week old male mice at with ejection fraction less than 70% exhibit increased left ventricular mass, increased left ventricular dimension at systole and left ventricular dimension at diastole, and reduced posterior wall thickness at diastole
• 31 week old females exhibit increased left ventricular dimension at systole
• patches of infiltration cells in hearts, however, the percentage of macrophages is not different from wild-type mice

immune system
• patches of infiltration cells in hearts, however, the percentage of macrophages is not different from wild-type mice

muscle
• older males show reduced ejection fraction and dilated left ventricle, indicating development of dilated cardiomyopathy
• females develop dilated cardiomyopathy at an older age and to a lesser extent than males
• ejection fraction is lower in 23-33 week old males; two groups are evident, those mice with ejection fraction greater than 70% and those with ejection fraction less than 70%
• 30-32 week old females show a modest, but significant, decline in ejection fraction
• a decline in ejection fraction begins around 16 weeks of age in males and after 24-28 weeks of age in females
• however, systolic blood pressure is normal in males and females at 28 weeks of age
• length of myocytes from 31-33 week old males is increased, whereas width is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:158439


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory