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Phenotypes Associated with This Genotype
Genotype
MGI:5906028
Allelic
Composition
Dhfrorana/Dhfr+
Genetic
Background
involves: C57BL/6JAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhfrorana mutation (0 available); any Dhfr mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• following exposure to 5-fluorouracil
• in untreated mice and following exposure to 5-fluorouracil
• prolonged following exposure to 5-fluorouracil

homeostasis/metabolism
N
• mice exhibit normal plasma homocysteine levels
• half as much total folate in the bone marrow as in wild-type mice
• however, sub-species levels are normal

cardiovascular system
• impaired endothelium-dependent in the aorta
• however, mice exhibit normal relaxation induced by the NO donor DEANO

immune system
• following exposure to 5-fluorouracil

muscle
• impaired endothelium-dependent in the aorta
• however, mice exhibit normal relaxation induced by the NO donor DEANO

growth/size/body
• following exposure to 5-fluorouracil


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory